01 - Preheat oven to 400°F. Line a baking sheet with parchment paper or lightly grease with nonstick spray.
02 - Pat the salmon fillets dry with paper towels and arrange on the prepared baking sheet, skin-side down if applicable.
03 - In a small bowl, whisk together the olive oil, Cajun seasoning, smoked paprika, garlic powder, salt, black pepper, lime zest, and lime juice until combined.
04 - Brush or spoon the spice mixture evenly over the top of each salmon fillet to coat completely.
05 - Place a slice of fresh lime on top of each seasoned fillet.
06 - Bake for 12 to 15 minutes, or until the salmon flakes easily with a fork and is opaque throughout.
07 - Remove from the oven, garnish with fresh cilantro or parsley if desired, and serve immediately.